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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, sensorgram showing wt IL-25–IL-17RB complex binding to immobilized IL-17RA. b, sensorgram showing no binding of IL-25–IL-17RB(L40A/R46E) mutant complex to immobilized IL-17RA. c, sensorgram showing no binding of IL-25–IL-17RB(D75A/R79E) mutant complex to immobilized IL-17RA. d, sensorgram showing no binding of IL-17RB to immobilized IL-17RA. e, sensorgram showing no binding of IL-17RA to immobilized IL-17RA. f, sensorgram showing no binding of IL-17RB to immobilized IL-17RB. g, sensorgram showing wt IL-25–IL-17RB complex binding to immobilized IL-17RB. h, sensorgram showing no binding of IL-25–IL-17RB(L40A/R46E) mutant complex to immobilized IL-17RB. i, sensorgram showing no binding of IL-25–IL-17RB(D75A/R79E) mutant complex to immobilized IL-17RB. j, sensorgram showing weak binding of IL-17RA to immobilized IL-17RB. Analyte concentration ranges are shown next to each sensorgram. Dissociation constants (Kd) are indicated on the sensorgrams. N.D. = Not Determined. Single experiments (n = 1) were performed for b, c, and e–j. Sensorgrams for a and d are representative of a single experiment from two independent experiments (n = 2).

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