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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, IL-17RA from the cryo-EM analysis superimposed with the 3JVF crystal structure, 5NAN crystal structure, and 4HSA crystal structure, in purple, green, blue, and pink, respectively. b, IL-17RA is stabilized by IL-17A binding. IL-17RA from the cryo-EM analysis superimposed with the unliganded 5N9B crystal structure, in purple and grey, respectively. Regions where the unliganded structure has unresolved loops are colored in yellow, while regions where the unliganded structure has less ordered secondary structure are colored in red.