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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Sequences were aligned using MUSCLE⁵³ and displayed, along with the secondary structure elements of IL-17RA from the IL-25–IL-17RB–IL-17RA ternary structure, using ESPript 3.0⁵⁴. Disulfide bonds are annotated with bright green letters. The D1 domain, D2 domain, TM region, and SEFIR domain of IL-17RA are underlined in black. Note the conservation of the region near the tip-to-tip interfaces as well as the insertion of the negatively charged loop in IL-17RC.