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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, 2D classifications of ternary IL-25–IL-17RB–IL-17RA complexes. Scale bar, 82 Å (2D class averages). b, Side view of the C2-symmetric cryo-EM map of the IL-25–IL-17RB–IL-17RA ternary complex reveals IL-17RA wings emanating from a core IL-25–IL-17RB complex. c, Side view of the ternary IL-25–IL-17RB–IL-17RA complex model shows that the D1 domain of IL-17RA interacts exclusively with the D1 domain of IL-17RB. Dashed lines indicate unmodelled linkers to the transmembrane regions of the receptors. Distances between the centres of masses of the D2 domains are shown. d, Top view of the IL-25–IL-17RB–IL-17RA complex model.