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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

Fig. 5. The tip-to-tip architecture is conserved in cryo-EM structures of IL-17A–IL-17RA and IL-17RA–IL-17A–IL-17RC complexes.

Fig. 5

a,b, Side views of the map (a) and model (b) of the IL-17A–IL-17RA tip-to-tip dimer. The structure consists of IL-17–IL-17RA complexes dimerized with each other via an IL-17RA–IL-17RA tip-to-tip interface. c,d, Top views of the map (c) and model (d) of IL-17–IL-17RA in a and b. e,f, Side views of the map (e) and model (f) of an IL-17A–IL-17RA complex bound to an IL-17RA–IL-17A–IL-17RC heterodimer via an IL-17RA–IL-17RA tip-to-tip interface. g, Superposition of the IL-17A–IL-17RA tip-to-tip dimer with the tip-to-tip components of the IL-25–IL-17RB–IL-17RA complex and higher-order IL-17RB–IL-17RB arrays reveals that the tip-to-tip architecture is conserved across IL-17–IL-17R complexes. Dashed lines indicate unmodelled linkers to the transmembrane regions of the receptors. Distances between the centres of masses of the membrane-proximal domains are shown in b, f and g. h, Signalling model of a shared IL-17–IL-17R mechanism in which the spacing of IL-17RA is important for transducing IL-17 signals. RC, IL-17RC.