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. 2022 Jul 21;609(7927):622–629. doi: 10.1038/s41586-022-05116-y

Extended Data Fig. 2. Cryo-EM density of IL-25–IL-17RB binary and IL-25–IL-17RB–IL-17RA ternary complexes.

Extended Data Fig. 2

a, Cryo-EM density of the IL-25 binary 2:2 complex with the model fitted. IL-25 is in blue and IL-17RB is in red. b, Selected regions of the map and model as in a. c, Cryo-EM density of the IL-25 ternary 2:2:2 complex with the model fitted. IL-25 is in blue, IL-17RB is in red, and IL-17RA is in purple. d, Selected regions of the map and model as in c. e, A resolved IL-17RA glycan, N67-NAG, near the tip-to-tip interface distinguishes IL-17RA from IL-17RB in the wing of the ternary complex in c. Models of IL-17RB (red and grey) and IL-17RA (purple) are docked into the cryo-EM density of the IL-25 ternary complex map.