FIGURE 5.

Smad3 binds to JUN to intervene in hBdSMC proliferation. (A) CUT and TAG sequencing was conducted. Smad3 was identified by specific motif from JASPAR. Gene ontology (GO) analyses were used to analyze the predicted target genes. (B) showed the biological process, analysis. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of target genes. (D) The four genes ranked by Peak_score from JASPAR. (E) The four groups in the dual‐luciferase reporter assay. NC, Natural control; Luc, Luciferase. Quantification is the mean ± SEM, n = 3. ****P < 0.0001. (F) Schematic overview of the effect of YAP on excess extracellular matrix ECM stiffness‐induced hBdSMC proliferation.