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. 2022 Sep 15;3(4):e173. doi: 10.1002/mco2.173

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© 2022 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Intervention therapy of epigenetic regulators targeting inflammation‐related diseases. Innate immune system responds to stimulus (bacteria, virus, lipopolysaccharide [LPS]) firstly, nevertheless exaggerated immune response results in a variety of inflammation‐related diseases. Epigenetic modifications including chromatin remodeling, DNA modifications, RNA modifications, Histone modifications, noncoding RNA, regulate multiple signaling pathways of chemokines, and cytokines released by immune cells in inflammation response. Biotherapeutics targeting epigenetics regulators have been studied as an important clinically effective treatments for inflammation‐related diseases (created with BioRender.com).