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. 2022 Sep 15;3(4):e173. doi: 10.1002/mco2.173

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© 2022 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inhibitors for targeting histone modifications regulators associated with inflammation response. Histone modifications mediated by histone acetyltransferases (HATs) (or HMT) and histone deacetylases (HDACs) result in activation chromatin state and repression chromatin state, respectively, which associated with inflammatory genes or genes responsible for innate immune response. Therefore, various small molecules and drugs are now under screening and trials to use them clinically to modify the altered epigenetic state and reduce the diseased condition (created with BioRender.com).