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. 2022 Sep 16;7:319. doi: 10.1038/s41392-022-01147-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — IL-27 p28 is a valuable marker for predicting aGVHD after allo-HSCT in humans. a IL-27 p28 production in patients after allo-HSCT were examined by ELISA. b ROC curve was constructed to predict severe aGVHD occurrence. c, d The cumulative incidence of severe aGVHD (c) and overall survival (d) between patients with high and low IL-27 p28 levels are shown. e, f Univariate analyses of factors associated with severe aGVHD occurrence (e) or overall survival (f) after allo-HSCT. g, h Multivariate analyses of factors associated with severe aGVHD occurrence (g) or overall survival (h) after allo-HSCT. i, j The associations between the expression of IL-27 p28 and IL-10 (i), and IFN-γ (j) were analyzed. Data are presented as mean ± SD. **P < 0.01