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. 2022 Sep 15;13:5417. doi: 10.1038/s41467-022-33121-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Superimposition of the agonist- and antagonist-bound LPA₁ structures, colored cyan and gray (PDB 4Z34), respectively, viewed from the membrane plane (a), the intracellular side (b), and the extracellular side (c). D251 in TM6 and Y311 in TM7 are shifted by about 8.2 and 4.1 Å, respectively. d–f Structural changes of the intramolecular interactions induced by agonist binding (d). Panels (e) and (f) are focused on the extracellular side of TM7 and the receptor core, respectively. Rearrangement of the PIF (g), NPxxY (h), and DRY (I) motifs upon receptor activation. Hydrogen bonds are indicated by black dashed lines.