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. 2022 Sep 15;13:5417. doi: 10.1038/s41467-022-33121-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Main hydrogen-bonding interactions between the receptor and the α5 helix of Gα_i1. b, c Structural comparisons of LPA₁-G_i with other GPCR-G-protein complexes at the interface, viewed from the cytoplasmic side (b) and membrane plane (c). Structural comparisons of the interactions between ICL2 and G_i in the NTSR1 C state (d), NTSR1 NC state (e), LPA₁ (f), and S1P₁ (g). Residues are shown as stick models. Hydrogen bonds are indicated by black dashed lines.