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. 2022 Sep 15;13:5417. doi: 10.1038/s41467-022-33121-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Superimposition of the LPA- and ONO-0740556-bound LPA₁ structures, colored green (PDB 7TD0) and cyan, respectively. b, c Superimposition of the binding pocket for LPA and ONO-0740556 in polar regions on the extracellular side (b), and in the hydrophobic pocket (c). d Superimposition of LPA-LPA₁-G_i states a (PDB 7TD1) and a’ (PDB 7TD2) aligned at the receptor. e Superimposition of S3 and S4 aligned at the receptor.