Fig. 3.

Components involved in RNS metabolism. Mutliple elements are involved in the RNS metabolism of which NO is the major component which is increased in the presence of oxidative stress. The increased NO reacts with oxygen to produce various nitrogen reactive radicals to induce the nitrosative stress which cause cell damage, mitochondrial dysfunction, and increased AHR. (NOS, nitric oxide synthase; MPO, myeloperoxidase; EPO, eosinophil peroxidase; SOD, superoxide dismutase). The figure was adapted from Rahman et al. (2006)