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. 2022 Sep 7;13(4):591–598. doi: 10.1007/s13340-022-00601-1

Fig. 1.

Fig. 1

Regulation of FoxOs by insulin signaling. Upper: a model for FoxOs regulation through insulin-induced and phosphorylation-dependent degradation. Lower: mice phenotypes in myeloid and endothelial cells-specific FoxO1/3a/4 knockout mice. ROS Reactive oxygen species, iNOS Inducible nitric oxide synthase, eNOS Endothelial nitric oxide synthase.