Table 3.
Top ten hub nodes in the PPI
| Rank | Symbol | Name | Degree of interaction |
|---|---|---|---|
| 1 | AKT1 | AKT serine/threonine kinase 1 | 27 |
| 2 | EGFR | epidermal growth factor receptor | 23 |
| 3 | SRC | "SRC proto-oncogene, non-receptor tyrosine kinase | 22 |
| 4 | MMP9 | matrix metallopeptidase 9 | 16 |
| 5 | MMP2 | matrix metallopeptidase 2 | 14 |
| 5 | KDR | kinase insert domain receptor | 14 |
| 7 | IGF1R | Insulin-like growth factor 1 receptor | 12 |
| 7 | PTK2 | protein tyrosine kinase 2 | 12 |
| 9 | ABCG2 | ATP binding cassette subfamily G member 2 | 10 |
| 10 | MET | "MET proto-oncogene, receptor tyrosine kinase | 9 |