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. 2022 Sep 2;13:928359. doi: 10.3389/fimmu.2022.928359

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Copyright © 2022 Jin, Chen, Wu, Lu, Li, Fu, Wang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of cTfh cell subsets in SLE patients. (A), Analysis of cTfh cell subsets by flow cytometry; (B), Percentage of cTfh1, cTfh2 and cTfh17 cells in cTfh cells from SLE patients: cTfh1 (CXCR3⁺CCR6^- cTfh), cTfh2 (CXCR3^-CCR6^- cTfh) and cTfh17 (CXCR3^-CCR6⁺ cTfh); (C), Percentage of ICOS⁺PD-1⁺ cTfh cells in cTfh cells from SLE patients; (D–F), Percentage of PD-1⁺ cTfh1, PD-1⁺ cTfh2, PD-1⁺ cTfh17 cells in cTfh cells from SLE patients; (G–I), Percentage of ICOS⁺PD-1⁺ cTfh1, ICOS⁺PD-1⁺ cTfh2, ICOS⁺PD-1⁺ cTfh17 cells in cTfh cells from SLE patients. Horizontal lines show the median. Statistically significant differences are indicated by the P value, *P<0.05;**P<0.01;***P<0.001.