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. 2022 Sep 15;13:5413. doi: 10.1038/s41467-022-33116-z

Fig. 7. A summary model linking inosine and immunotherapy responses.

Fig. 7

The metabolic imbalance, especially inosine, is associated with immunotherapy responses in mice and humans. Inosine overcomes tumour-intrinsic resistance to immunotherapy by inhibiting UBA6 and increasing tumour immunogenicity in tumours with UBA6-high expression.