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. 2022 Sep 2;13:976356. doi: 10.3389/fgene.2022.976356

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Copyright © 2022 Ren, Wang, Zeng, Li, Chen, Peng, Bhawal and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening important hypoxia-driven genes associated with poor outcome in glioma tis-sues. (A) Volcano plot indicating DEGs between glioma patients with poor (progressive disease, PD) or favorable (complete response, CR + partial response, PR + stable disease, SD) outcomes. (B) Intersection analysis demonstrated that 163 genes were up-regulated in gliomas with high-hypoxia and poor outcome. (C) Intersection analysis demonstrated that 6 genes were down-regulated in gliomas with high hypoxia and poor outcome. (D) PPI network of 169 important hypoxia driven genes associated with outcome in glioma. (E) Degree score of genes in the PPI network ≥10.