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. 2022 Sep 2;13:976356. doi: 10.3389/fgene.2022.976356

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Copyright © 2022 Ren, Wang, Zeng, Li, Chen, Peng, Bhawal and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of risk model. (A) Univariate COX analysis for the 22 important hypoxia-driven genes. Blue indicates genes that act as predictors of a favorable prognosis, while red indicates genes that act as predictors of an unfavorable prognosis. (B,C) LASSO penalized Cox regression analysis exhibiting the 13 important hypoxia-driven genes. (D) Multivariate COX regression analysis selected 6 important hypoxia-driven genes to construct the risk model. HOXC6, MMP9. SHOX2 and MYOD1 can act as an independent prognostic factor.