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. 2022 Sep 2;13:976356. doi: 10.3389/fgene.2022.976356

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Copyright © 2022 Ren, Wang, Zeng, Li, Chen, Peng, Bhawal and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SHOX2 linked to hypoxia and TMZ-resistance. (A) CCK-8 was used to determine the IC50 of TMZ in 48 h for U87, A172, SF268, LN-18, U373 and T98 cells. (B,C) Western blot was used to determine the expression of SHOX2 in U87, A172, SF268, LN-18, U373 and T98 cells. (D,E) Western blot was used to determine the expression of SHOX2 in U87 and A172 cells under hypoxia for 0, 3, 6 and 12 h (F,G) Western blotting was to determine the expression of SHOX2 in U87 and A172 after treatment with siRNAs. (H) CCK-8 assays were used to determine the effects of SHOX2 on TMZ-resistance under hypoxia. (I,J) Colony formation assays were used to determine the effects of SHOX2 on TMZ-resistance under hypoxia. **, p < 0.01.