Figure 10.

Survival rate (A), severity score (B) and body weight loss (C) of mice at 7 days after cecal ligation and puncture (CLP). Mice were subjected to CLP and received colivelin (100 µg/kg subcutaneously) or vehicle at 1 h, 3 h and 24 h after CLP. All mice received fluid resuscitation (35 ml/kg normal saline with 5% dextrose subcutaneously) every 24 h up to 7 days and ceftriaxone (25 mg/kg) and metronidazole (12.5 mg/kg) intraperitoneally every 12 h up to 3 days after the CLP procedure. *Represents P < 0.05 versus colivelin-treated mice.