Figure 2.

Representative histology photomicrographs of lung sections of a control mouse (A) or mice subjected to polymicrobial sepsis at 6 h (B) and 18 h (C) after cecal ligation and puncture (CLP). Lung damage at 6 h and 18 h after CLP was characterized by severe reduction of alveolar space, neutrophil adhesion along vascular wall, hemorrhage, and infiltration of inflammatory cells. Magnification x100. A similar pattern was seen in tissue sections of n=5 mice in each experimental group. (D) Histopathologic scores of lung sections (n=5 mice for each group). Lung injury was scored from 0 (no damage) to 16 (maximum damage). Box plots represent 25^th percentile, median, and 75^th percentile; error bars define 10^th and 90^th percentiles. *Represents P < 0.05 versus control mice at time 0.