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. 2022 Sep 2;13:984298. doi: 10.3389/fimmu.2022.984298

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Copyright © 2022 Urban, Hayes, Piraino, Wolfe, Lahni, O’Connor, Phares and Zingarelli

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative Western blots of total STAT3, p-STAT3(Ser727) and p-STAT3(Tyr705) in lung cytosol and nuclear extracts; β-actin was used as loading control protein (A). Image analyses of cytosol and nuclear of relative intensity of total STAT3 (B), ratio of p-STAT3(Ser727)/STAT3 (C), and ratio of p-STAT3(Tyr705)/STAT3 (D) as determined by densitometry. Vehicle (200 µl distilled water) or colivelin (100 µg/kg) was administered intraperitoneally at 1 h after CLP. Each data represents the mean ± SEM of 3-4 mice for group (n=3 control group, n=4 vehicle group, n=4 colivelin 100 µg group). *Represents P < 0.05 versus control mice; #represents P < 0.05 versus vehicle-treated mice.