Table 3.
The comparison of epidemiology and etiology of HFMD between vaccinated and unvaccinated cases during 2017 to 2020.
| Total N = 3367(%) |
Vaccinated n = 2478(%) |
Unvaccinated n = 889(%) |
P | OR(95% CI) | ||||
|---|---|---|---|---|---|---|---|---|
| Age group (yr) | .905 | |||||||
| <1 | 17 | (0.5) | 12 | (0.5) | 5 | (0.6) | .778 | 0.86(0.30-2.45) |
| 1~ | 2083 | (61.9) | 1529 | (61.7) | 554 | (62.3) | .746 | 0.97(0.83-1.14) |
| 2~ | 667 | (19.8) | 491 | (19.8) | 176 | (19.8) | .991 | 1.00(0.83-1.21) |
| 3~ | 364 | (10.8) | 272 | (11.0) | 92 | (10.3) | .605 | 1.07(0.83-1.37) |
| 4~ | 154 | (4.6) | 110 | (4.4) | 44 | (4.9) | .532 | 0.89(0.62-1.28) |
| ≥5 | 82 | (2.4) | 64 | (2.6) | 18 | (2.0) | .354 | 1.28(0.76-2.18) |
| Gender | ||||||||
| Male | 2119 | (62.9) | 1545 | (62.3) | 574 | (64.6) | .240 | 0.91(0.78-1.07) |
| Female | 1248 | (37.1) | 933 | (37.7) | 315 | (35.4) | Referent | |
| Hosting classification | .902 | |||||||
| Scatter children | 2526 | (75.0) | 1857 | (74.9) | 669 | (75.3) | .853 | 0.98(0.82-1.17) |
| Childcare | 786 | (23.3) | 581 | (23.4) | 205 | (23.1) | .815 | 1.02(0.85-1.23) |
| In school | 47 | (1.4) | 35 | (1.4) | 12 | (1.3) | .891 | 1.05(0.54-2.03) |
| Others | 8 | (0.2) | 5 | (0.2) | 3 | (0.3) | .756 | 0.60(0.14-2.50) |
| Etiology | .291 | |||||||
| EV71 | 441 | (13.1) | 319 | (12.9) | 122 | (13.7) | .519 | 0.93(0.74-1.16) |
| CV-A16 | 351 | (10.4) | 245 | (9.9) | 106 | (11.9) | .088 | 0.81(0.64-1.03) |
| Others | 1989 | (59.1) | 1476 | (59.6) | 513 | (57.7) | .334 | 1.08(0.92-1.26) |
| Negative | 586 | (17.4) | 438 | (17.7) | 148 | (16.6) | .488 | 1.08(0.88-1.32) |
| Severity | ||||||||
| Severe | 180 | (5.3) | 126 | (5.1) | 54 | (6.1) | .261 | 0.83(0.60-1.15) |
| Mild | 3187 | (94.7) | 2352 | (94.9) | 835 | (93.9) | Referent | |
CI = confidence interval, CV-A16 = coxsackievirus A16, EV71 = enterovirus 71, HFMD = hand-foot-and-mouth disease, OR = odds ratio.