Figure 2.

ATM recruitment. Obesity promotes adipocyte death as well as adipose tissue inflammation, which firstly trigger a large number of chemokines secretion, including CCL2. Upon activation, monocytes and vascular endothelial cells produce various cellular adhesion molecules, mainly integrin, ICAM-1 and VCAM-1. Through rolling and adhesion process, monocytes bind to adhesion molecules on vascular endothelial cells and transmigrate from blood vessel to target adipose tissue. Eventually, recruited monocytes differentiate into proinflammatory macrophages in response to local microenvironmental stimuli.