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. 2022 Sep 2;13:989298. doi: 10.3389/fimmu.2022.989298

Figure 1.

Figure 1

The structures of heterogeneous ribonucleoproteins from hnRNP A1 to RALY. HnRNPs have different structures using some shared and distinctive elements. RRM: RNA recognition motif, KH: K-homology domain, RGG-box: motifs containing arginine and glycine repeats, M9: M9 sequence, Gly-rich: glycine-rich domain, bZLM: basic leucine zipper-like motif, Acidic-rich: acidic-rich domain, Q-rich: Glutamine-rich domain, Exon: The splicing site of enzyme to create various mRNAs, therefore translated into different proteins, NLS: nuclear localization sequence, KI: K-interaction domain, Pro-rich: Proline-rich domain, KNS: nuclear shuttling domain, MR-repeat: methionine and arginine repeat motif, QGSY-rich: (glutamine-glycine-serine-tyrosine)-rich region, Q/N-rich: glutamine- and/or asparagine-rich region. RRMs and KH domains are usually responsible for virus RNA recognition and binding, and M9 and NLS are mainly responsible for hnRNP nuclear retention.