Figure 3.
Functions of hnRNP D in enterovirus replication. During enterovirus infection, hnRNP D translocates from nucleus to cytoplasm in a 2A protein-dependent manner. The presence of hnRNP D could restrict enterovirus RNA replication. Enterovirus 3C/3CD could cleave hnRNP D and disable it from inhibiting virus RNA replication (85, 86).