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. 2022 Sep 13;21:299–312. doi: 10.1016/j.bioactmat.2022.08.028

Fig. 1.

Fig. 1

Preparation and characterizations of EHGZ after encapsulation of EPI, Gox and hemin into ZIF-8 nanoparticles and mEHGZ after coating of the drug-loaded nanoparticles with tumor cell membrane. A) TEM images of EHGZ and mEHGZ, scale bar = 100 nm. B) EDS elemental mapping images of mEHGZ for element C, N, O, Zn, Fe and P, scale bar = 30 nm. C-D) DLS sizes and zeta potentials of ZIF-8, EZ, GHZ, EHGZ, and mEHGZ. E) XRD patterns of ZIF-8, EZ, GHZ, EHGZ, and mEHGZ. F) The release profiles of EPI from EHGZ at pH of 7.4 and 5.4. G-H) Western blotting and coomassie blue staining images of cell membrane (Cm), EPI-treated membrane (Em), EHGZ and mEHGZ. I) Flow Nano Analyzer results to determine the coating efficiency of the cell membrane onto the drug-loaded ZIF-8 nanoparticles.