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. 2022 Sep 2;15:964632. doi: 10.3389/fnmol.2022.964632

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Copyright © 2022 Perera, Tolomeo, Baker, Ohene, Korsak, Lythgoe, Thomas and Wells.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CSF homeostasis: T1_CSF and lateral ventricular volume. (A) T1_CSF values from WKY and SHR subjects, extracted from BCSFB-ASL multi-TI data. Error bars: ± SEM (n = 6 WKY, 6 SHR). (B) Example of multi-TI inversion recovery fitting (n = 1 WKY, 1 SHR). Error bars: ± stdev (20 repetitions at each TI). (C) Lateral ventricular volume values from WKY and SHR subjects, from T2-weighted anatomical images. Error bars: ± SEM (n = 6 WKY, 6 SHR). (D) Examples of T2-weighted anatomical images (equivalent slices) displaying ventriculomegaly (n = 1 WKY, 1 SHR). Asterisks: 2-tailed t-test significance, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.