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. 2022 Sep 2;10:971739. doi: 10.3389/fbioe.2022.971739

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Copyright © 2022 Kwon, Jo, Song, Lee, Jeon, Park, Kim, Baek, Kim, Kwon, Kim, Yang and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of proteomics results for Caco-2 cells in coculture with C. difficile at 12 h versus monoculture. (A) Volcano plot for comparison of proteomic differences with respect to coculture with C. difficile at 12 h. Volcano plots indicate the upregulated proteins of Caco-2 cells during coculture with C. difficile in red circles and downregulated proteins in blue circles. Indications denote the proteins discussed in this study. (B) Principal component analysis (PCA) plot for comparison of proteomic differences according to coculture with C. difficile at 12 h. Control means monoculture of Caco-2 cells. Proteomic analysis was performed in triplicate.