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. 2022 Sep 2;10:971739. doi: 10.3389/fbioe.2022.971739

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Copyright © 2022 Kwon, Jo, Song, Lee, Jeon, Park, Kim, Baek, Kim, Kwon, Kim, Yang and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The antioxidant role of glutathione S-transferase in Caco-2 cells during coculture with C. difficile. (B) Proteomic changes in glutathione S-transferases in Caco-2 cells during coculture with C. difficile. Proteomic analysis was performed in triplicate. (C) Comparison of the production of glutathione in Caco-2 cells cultured with C. difficile. The error bars represent the standard deviation. Metabolomic analysis was performed in quadruplicate. GST, glutathione S-transferase; MGST2, microsomal glutathione S-transferase 2; GSTA3, glutathione S-transferase 3; GSTZ1, glutathione S-transferase Zeta 1. *p < 0.05, **p < 0.01, ***p < 0.001.