TABLE 1.

List of identified proteins involved in the mitochondrial electron transfer chain. Proteomic analysis was performed in triplicate.

UniProt ID	Gene names	Protein names	Log2FC (C. difficile/control)
1 Mitochondrial ATP synthase
O75964	ATP5MG	ATP synthase subunit g	−0.978*
P56385	ATP5ME	ATP synthase subunit e	−1.144*
P00846	ATP6	ATP synthase membrane subunit 6	−1.389*
P18859	ATP5PF	ATP synthase-coupling factor 6	−0.836**
P06576	ATP5F1B	ATP synthase F1 subunit beta	−0.807*
P25705	ATP5F1A	ATP synthase F1 subunit alpha	−0.734*
P48047	ATP5O	ATP synthase subunit O	−1.122**
2 Electron transport chain
O00217	NDUFS8	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8	−0.940*
Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	−1.034*
Q9Y6M9	NDUFB9	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	−1.222*
O75251	NDUFS7	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7	−2.225*
P28331	NDUFS1	NADH-ubiquinone oxidoreductase 75 kDa subunit 1	−0.823*
Q99643	SDHC	Succinate dehydrogenase cytochrome b560 subunit	−1.651*
P14927	QCR7	Cytochrome b-c1 complex subunit 7	−0.862*
P22695	QCR2	Cytochrome b-c1 complex subunit 2	−1.028*
P10606	COX5B	Cytochrome c oxidase subunit 5B	−1.107*
P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1	−0.918**
P14406	COX7A2	Cytochrome c oxidase subunit	−0.928*
P15954	COX7C	Cytochrome c oxidase subunit 7C	−1.112*
P14854	COX6B1	Cytochrome c oxidase subunit 6B1	−1.129**
Q9Y2R0	COA3	Cytochrome c oxidase assembly factor 3	−1.039*

*p < 0.05, **p < 0.01, ***p < 0.001.