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. 2022 Aug 25;24(4):358. doi: 10.3892/ol.2022.13478

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Schematic illustrating the principle of CAR-T cell therapy: Lymphocytes are obtained from patients and T cells are isolated. These T cells are transferred into specific CAR genes through viral or non-viral vectors and thereby transformed into CAR-T cells. These CAR-T cells are expanded in vitro and returned to the patient's body to identify and kill tumor cells specifically. CAR-T, chimeric antigen receptor T-cell; VL, variable region of light chain; VH, variable region of heavy chain.