TABLE 3.

Cardiovascular and nervous system groups, drug mix, annual volume, and expenditure in 2012 and in 2018 and variations in the period. Minas Gerais, Brazil.

Therapeutic group a	Drug mix						Annual volume (millions)			Annual expenditure USD (millions) b
	Chemical substance			Pharmaceutical products c
	2012	2018	Variation d (%)	2012	2018	Variation d (%)	2012	2018	Variation d (%)	2012	2018	Variation d (%)
C—Cardiovascular system
C01—Cardiac therapy	3	7	167	4	12	200	26.09	12.50	−52.11	0.51	0.77	52.78
C02—antihypertensives	2	3	50	3	5	67	22.48	15.46	−31.20	1.16	1.01	−13.10
C03—diuretics	3	3	0	3	5	67	185.68	106.13	−42.84	0.99	1.16	17.64
C07—beta blocking agents	4	4	0	5	12	140	133.95	98.61	−26.38	2.62	2.84	8.18
C08—calcium channel blockers	2	3	50	2	5	150	51.05	52.65	3.12	0.32	0.44	38.47
C09—agents acting on the renin–angiotensin system	3	3	0	5	5	0	353.29	193.20	−45.31	2.53	1.50	−40.48
C10—lipid modifying agents	1	1	0	2	3	50	44.05	64.95	47.44	0.73	1.18	60.77
Total	18	24	33	24	47	96	816.59	543.50	−33.44	8.85	8.90	0.56
N—Nervous system
N01—anesthetics e	0	4	-	0	6	-	0	0.01	-	0	0.02	-
N02—analgesics	2	3	50	3	6	100	52.80	33.13	−37.25	0.86	0.97	12.33
N03—antiepileptics	5	5	0	9	12	33	113.48	87.79	−22.64	3.00	3.24	7.96
N04—anti-parkinson drugs	3	3	0	4	5	25	20.13	18.83	−6.49	0.73	2.25	207.24
N05—psycholeptics	4	5	25	10	14	40	78.49	40.05	−48.97	1.29	1.68	30.28
N06—psychoanaleptics	5	4	−20	6	9	50	81.21	76.99	−5.19	1.72	2.35	37.12
Total	19	24	26	32	52	63	346.11	256.81	−25.80	7.61	10.51	38.13

^aATC, second level.

^b1USD, 3.8742 BRL.

^cPharmaceutical products including all chemical substances in their different dosage forms and strengths.

^dVariation = [(∑2018-∑2012)/∑2012]∗100.

^eN01-anesthetics were only acquired in 2018.