TABLE 3.

Neuroendocrine tumor, sickness of Alzheimer, and disease of Parkinson animal models are summarized.

Disease	Model	Characteristics	Reference	Plant name	Part used	Neuroprotective activity	Reference
GMB	Xenograft/HT1080 (human cell line)	IDH1 mutant (MGG152)	Tateishi et al. (2015)	Fumaria indica (Hausskn.) Pugsley	Leaf	Significant activity of ethanolic extract on rat cognitive dysfunctions. Potential antianxiety activity of leaf extract; preclinical study	(Singh et al., 2013a; Singh et al., 2013b)
	Xenograft/LNT-229 and LN-308 (human cell line)	IDH1 R132C mutant (HT1080)	Szabo et al. (2016)
	Xenograft/BT111 (TIC), BT116 (TIC)	Unmethylated MGMT (BT111) and (BT116)	Sharpe et al. (2015)
	Xenograft/U251 (human cell line)	N/A	Sharpe et al. (2015)	Alhagipseud alhagi (M. Bieb) Desv. ex B. Keller &Shap.	Whole plant	Traditionally used for neuroprotective disorders. Compounds having neuroprotective activity such as flavanone glycosides and alkaloids such as β-phenethylamine and tetrahydroisoquinoline have been reported	(Ghosal et al., 1974; Singh et al., 1999; Muhammad et al., 2015)
	Allograf GL261-Luc (mouse cell line)	N/A	Zeng et al. (2013)
AD	PDAPP	Unspecified microgliosis and resistant microglia are both related to diseases	Cohen et al. (2013)	Premna mucronata Roxb	Whole plant	Luteolin and apigenin are reported, and they are reported to be neuroprotective	Dave et al. (2015)
	Tg2576	Plaques are related to neural stem cells that have been allocated a particular character	Elfenbein et al. (2007)
	APP23	In specifically, the glial cell is associated in fibrils deposits, epidemic, and also cytosis	Karch and Goate, (2015)	Semecarpus anacardium L.f	Fruits	Stress-induced neuroprotective activity	Shukla et al. (2000)
	J20	Microgliosis and astrogliosis are two forms of engraftment that may occur in the brain and have negative consequences	(Hartley et al., 2015)	Sida cordifolia L	Whole plant	Ameliorative effect in parkinsonism	SJ and Kumar B, (2020)
PD	MPTP Neurotoxin: inhibition of complex I	No time passes during the process of accumulation, and cholinergic neurotoxicity occurs quickly and severely, resulting in a major motor deficit	Dauer and Przedborski, (2003)	Tinospora cordifolia (Thunb.) Miers	Stems	Suppresses neuro-inflammation in Parkinsonian Mouse Model; potential neuro-regenerative candidate against glutamate induced excitotoxicity: an in vitro perspective	(Sharma et al., 2018; Birla et al., 2019)
	6-OHDA Suppression of 6-OHDA suppression of enzyme I as well as antioxidant distress caused by neurotoxic	Heterogeneous sensory impairments, no synuclein aggregation, fast and severe cholinergic deterioration	Schober and research, (2004)	Trichosanthes dioica Roxb	Rhizome	Neuropharmacological properties of root	Bhattacharya and Haldar, (2013)
	UCH-L1 I93M mutation	In rodents, there were no synuclein aggregation, cholinergic neurotoxicity, or minor motor impairments	Setsuie et al. (2007)