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CISE-ET inhibited the entry of MERS-CoV, SARS-CoV and SARS-CoV-2. Huh7 cells were transduced with MERS-CoV (A), SARS-CoV (B), SARS-CoV-2 (C) or VSV (D) pseudotyped viruses (pvs) in the presence of various concentrations of CISE or CISE-ET. The viral entry was quantified by a luciferase assay at 48 h post-transduction and expressed relative to that found for the DMSO control group. The error bars represent the SDs from the means (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001.
