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. 2022 Sep 2;12:934080. doi: 10.3389/fonc.2022.934080

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Copyright © 2022 Wu, Han, Su, Xuan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of risk signature in the TARGET cohort. (A) Univariate Cox regression analysis of overall survival for each fatty acid and lactate metabolism–related gene, and three genes with P < 0.05. (B) Cross-validation for tuning the parameter selection in the LASSO regression. (C) LASSO regression of the three overall survival-related genes. (D) Distribution of patients based on the risk score. (E) The survival status of low-risk and high-risk population. (F) PCA plot for osteosarcoma patients based on the risk score. (G) The t-SNE analysis based on the risk score. (H) Kaplan–Meier curves for the overall survival of patients in the high- and low-risk groups. (I) ROC curves demonstrated the predictive efficiency of the risk score.