TABLE 1.
PBPK-PD model parameters for tau expression and turnover in humans.
| Parameter description | Parameter | Units | Value | References |
|---|---|---|---|---|
| Baseline tau in CSF | Tau0_CSF | pM | 27.0 | 29566794, 25720406 |
| Baseline tau in brain ISF | Tau0_ISF | pM | 68.6 | 25720406 |
| Baseline ptau in CSF | pTau0_CSF | pM | 1.83 | 29566794, 25720406 |
| Baseline ptau in brain ISF | pTau0_ISF | pM | 7.41 | 25720406 |
| Percent ptau to total tau in CSF | — | % | 6.79 | 25720406 |
| Percent ptau to total tau in ISF | — | % | 10.8 | 25720406 |
| CSF ptau production rate | Kin_CSF | fM/h | 1.75 | 29566794, 25720406 |
| Brain ISF ptau production rate | Kin_ISF | fM/h | 7.06 | Assumption |
| ptau half-life | — | Days | 30.7 | 29566794 |
| ptau elimination rate | Kout | 1/h | 0.000941 | 29566794 |
| Complex degradation rate | Kdeg | 1/h | 0.001 | Assumption |