Figure 3.

Chimeric evasins display distinct chemokine binding selectivity profiles. Bar diagrams showing binding affinity (K_d) of CC chemokines to: A, EVA-R, EVA-4 and their chimeras; B, EVA-R, EVA-P, and their chimeras; C, EVA-R, EVA-1, and their chimeras; and D, EVA-1, EVA-P, and their chimeras. In each panel, the bar diagrams for the relevant wildtype proteins are repeated for ease of direct comparison to the chimeras. Bars represent mean ± SD of three independent measurements. The K_d for binding of EVA-P to CCL8 and CCL16 is tighter than the measurable limit (∼0.1 nM).