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. 2022 Sep 2;13:915001. doi: 10.3389/fimmu.2022.915001

Table 5.

Wild bootstrapping multivariate regression of hypertension with humoral and cellular response parameters as dependent variables in infected health care workers.

Cellular and humoral response parameters B Bias Std. Error Sig. BCa 95% Confidence Interval
Lower Upper
SARS-CoV-2 IgG-Ab (S1) (BAU/ml) a 238.119 -5.462 80.72 0.013 91.835 376.501
SARS surrogate neutralization test (%) b 16.544 -.891 6.747 0.020 4.892 26.704
Spike-N-Term LTT (SI) c 6.599 0.062 3.153 0.078 0.325 12.943
Spike-C-Term LTT (SI) d 4.792 0.058 2.456 0.066 0.045 9.805

The multiple regression models were performed with humoral and cellular response parameters as one dependent variable, respectively, i.e., SARS-CoV-2 IgG-Ab (S1) (BAU/ml) in model a, and R2 of the model is 0.255; SARS surrogate neutralization test (%) in model b, and R2 of the model is 0.194; Spike-N-Term LTT (SI) in model c, and R2 of the model is 0.304; Spike-C-Term LTT (SI) in model d, and R2 of the model is 0.260. We include confounding factors such as age (years), sex (M/F), BMI (body mass index, calculated as weight in kilograms divided by height in meters squared), diabetes (yes/no), hypertension (yes/no), chronic obstructive pulmonary disease (COPD) (yes/no), asthma (yes/no), smoking (yes/no), time from infection to blood collection (days) into the models. BCa, Bias-corrected and accelerated. Details of the individual models are shown in Supplementary Table 1 .