Immunohistochemistry of Sam68. (A) Representative images of healthy mucosal epithelium adjacent to OSCC, in which Sam68 expression was predominantly detected in the nucleus and negatively observed in the cytoplasm (magnification, ×100 and ×200; scale bar, 50 µm). (B) Representative image of OSCC, in which Sam68 expression was detected both in the nucleus and cytoplasm (magnification, ×100 and ×200; scale bar, 50 µm). (C-E) Nuclear expression of Sam68 with (C) weak, (D) moderate, and (E) strong staining intensity in OSCC cells (magnification, ×200; scale bar, 50 µm). (F-H) Cytoplasmic expression of Sam68 with (C) weak, (D) moderate, and (E) strong staining intensity in OSCC tissue (magnification, ×200; scale bar, 50 µm). Sam68, Src-associated in mitosis 68 kDa; OSCC, oral squamous cell carcinoma.