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. 2022 Aug 15;122(17):13883–13914. doi: 10.1021/acs.chemrev.1c00879

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© 2022 The Authors. Published by American Chemical Society

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(A–C) Optical microscopy of several crystalline compounds suitable for 3D electron crystallography. (A,C) Formally recrystallized material (an organic small molecule suspended in glycerol in A, an oligopeptide suspended in a hanging drop in C) requiring additional pulverization before ED due to their macroscopic size. (B) An inherently microcrystalline powder amenable to a direct “shake-n-bake” approach with a standard 3.05 mm lacey carbon EM grid, encircled in blue. (D–F) Transmission electron microscopy reveals micro- and nanocrystalline specimens with a range of morphologies, all suitable for ED analysis.