Figure 8.

Ab initio atomic-resolution 3D ED structures of three novel oligopeptide fragments derived from pathologically relevant proteins. Carbon atoms and the peptide backbone are rendered in blue, oxygen atoms in orange, and nitrogen atoms in purple. (A) 1.0 Å resolution structure of ³¹²NFGEFS³¹⁷ (PDB 5WKB), a hexapeptide segment from the low-complexity domain of the A315E familial mutant of TAR DNA-binding protein 43. (B) 0.75 Å resolution structure of ¹⁶⁸QYNNQNNFV¹⁷⁶ (PDB 6AXZ), a nonapeptide segment from the β2−α2 loop of the bank vole prion protein. (C) 1.1 Å resolution structure of ²⁰FAEiDVGSNKGAIIGL³⁴ (PDB 6OIZ), a 15-residue segment from wild-type amyloid-β.