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. 2022 Sep 2;13:952528. doi: 10.3389/fgene.2022.952528

TABLE 1.

Relationship between clinical factors and LATS2 expression in ESCC.

Characteristic Level Low expression of LATS2 High expression of LATS2 p
N 81 81
T stage, n (%) T1 15 (20.5%) 12 (16.7%) 0.268
T2 19 (26%) 18 (25%)
T3 39 (53.4%) 38 (52.8%)
T4 0 (0%) 4 (5.6%)
N stage, n (%) N0 36 (49.3%) 30 (42.3%) 0.701
N1 30 (41.1%) 33 (46.5%)
N2 5 (6.8%) 4 (5.6%)
N3 2 (2.7%) 4 (5.6%)
M stage, n (%) M0 61 (93.8%) 60 (93.8%) 1.000
M1 4 (6.2%) 4 (6.2%)
Pathologic stage, n (%) Stage I 9 (12.5%) 7 (10%) 0.599
Stage II 38 (52.8%) 31 (44.3%)
Stage III 21 (29.2%) 28 (40%)
Stage IV 4 (5.6%) 4 (5.7%)
Radiation therapy, n (%) No 52 (70.3%) 55 (78.6%) 0.343
Yes 22 (29.7%) 15 (21.4%)
Primary therapy outcome, n (%) PD 5 (9.4%) 5 (12.2%) 0.836
SD 3 (5.7%) 4 (9.8%)
PR 2 (3.8%) 1 (2.4%)
CR 43 (81.1%) 31 (75.6%)
Gender, n (%) Female 10 (12.3%) 13 (16%) 0.653
Male 71 (87.7%) 68 (84%)
Race, n (%) Asian 22 (28.9%) 16 (23.5%) 0.035
Black or African American 6 (7.9%) 0 (0%)
White 48 (63.2%) 52 (76.5%)
Age, n (%) ≤60 41 (50.6%) 42 (51.9%) 1.000
>60 40 (49.4%) 39 (48.1%)
BMI, n (%) ≤25 44 (56.4%) 40 (53.3%) 0.826
>25 34 (43.6%) 35 (46.7%)
Histological type, n (%) Adenocarcinoma 26 (32.1%) 54 (66.7%) <0.001
Squamous cell carcinoma 55 (67.9%) 27 (33.3%)
Histologic grade, n (%) G1 11 (16.7%) 5 (8.3%) 0.346
G2 34 (51.5%) 32 (53.3%)
G3 21 (31.8%) 23 (38.3%)
Smoker, n (%) No 25 (34.2%) 22 (31%) 0.811
Yes 48 (65.8%) 49 (69%)
Alcohol history, n (%) No 19 (24.4%) 27 (33.3%) 0.283
Yes 59 (75.6%) 54 (66.7%)
Barrett’s esophagus, n (%) No 52 (82.5%) 54 (78.3%) 0.690
Yes 11 (17.5%) 15 (21.7%)
Tumor central location, n (%) Distal 51 (63.7%) 62 (76.5%) 0.196
Mid 25 (31.2%) 17 (21%)
Proximal 4 (5%) 2 (2.5%)
Age, median (IQR) 60 (54, 70) 60 (53, 75) 0.519