FIGURE 2.

The administration of LPI and CBD in the GPe generated lower levels of 6-OHDA-induced motor asymmetry. (A) Amphetamine-induced turning behavior (5 mg/kg) was evaluated 14 days after the 6-OHDA injection into the MFB, with all animals placed into two groups–vehicle and 6-OHDA. The 6-OHDA group showed an increase in the number of ipsilateral turns per minute, in contrast to the vehicle group, which did not show any ipsilateral turns. (B) Six experimental groups were formed in order to evaluate the amphetamine-induced turning behavior presented by the animals after the intrapallidal administration of 1 µL [LPI 10 µM], [CBD 10 µM], or vehicle (DMSO 0.01%) on the 30th day post-lesion. Lower levels of 6-OHDA-induced motor asymmetry in 6-OHDA + LPI and 6-OHDA + CBD groups, a finding which contrasts with the 6-OHDA + DMSO. Data are represented as the mean ± SEM of ipsilateral turns per minute (10 periods of 10 min). ^*** p < 0.001 vs. vehicle; ⁺⁺⁺ p < 0.001 vs. vehicle + DMSO 0.01%; ^# p < 0.05, ^## p < 0.01 and ^### p < 0.001 vs. 6-OHDA + DMSO 0.01%; a two-way ANOVA followed by a Bonferroni post-hoc test, (n = 6–8/group).