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. 2022 Sep 2;13:978625. doi: 10.3389/fphar.2022.978625

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Copyright © 2022 Brockmueller, Mueller, Shayan and Shakibaei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of resveratrol or/and ASO against β1-integrin or against NF-κB on TME-promoted activation of EMT-linked biomarkers in CRC cells. 3D-alginate RKO (A) and HCT116 (B) CRC cells were detected against E-cadherin, vimentin, slug and loading controlled with β-actin after 10–14 days of treatment. X-axis: untreated (Ba.Co.), TME control, resveratrol (1, 5 µM), β1-SO/ASO (0.5 µM), NF-κB-SO/ASO (0.5 µM) or combination of 0.5 µM SO/ASO and resveratrol (5 µM). Y-axis: Densitometric units (y-axis) complementing Western blot results and for analysis, data were compared to TME control: *p < 0.05 and **p < 0.01 were considered statistically significant.