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. 2022 Sep 2;9:977653. doi: 10.3389/fmolb.2022.977653

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Copyright © 2022 Sump and Brickner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for the mechanism of inheritance of H3K4me2 during epigenetic transcriptional memory. During memory, H3K4me2 is both protected from demethylation by SET3C and, through interaction with COMPASS, SET3C H3K4me2 is maintained (top). Following DNA replication (bottom), H3K4me2-modified nucleosomes are reincorporated locally, along with unmodified nucleosomes. SET3C binding of H3K4me2 through its PHD domain facilitates recruitment of COMPASS/PAF1C, which demethylates unmodified nucleosomes nearby.