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. 2022 Sep 2;12:860084. doi: 10.3389/fonc.2022.860084

Table 1.

Survival analysis of HCC patients.

Variable All cases (73) Median OS ± SD (months) UV UV MV MV
P value HR (95% CI) P value HR (95% CI)
Sex
Male 17 20.88 ± 17.613 0.011 2.700(1.261-5.778) 0.295
Female 56 27.52 ± 15.657
Age
>60 25 24.12 ± 14.692 0.317 1.466(0.693-3.099)
<=60 48 26.9375 ± 17.079
Smoking
No 46 25.3 ± 17.433 0.094 2.082(0.882-4.911) 0.72
Yes 27 27.11 ± 14.262
Drinking
No 55 24.80 ± 17.297 0.234 1.800(0.683-4.739)
Yes 18 29.56 ± 12.263
Tumor size
<6 44 29.227 ± 16.127 0.074 1.968(0.936-4.138) 0.209
>=6 29 21.03 ± 15.426
LNs metastasis
No 65 27.83 ± 15.969 3.77E-06 7.896(3.288-18.959) 7.00E-06 7.901(3.214-19.419)
Yes 8 10.88 ± 9.643
Satellite stove
Negative 54 27.98 ± 15.559 0.053 2.151(0.991-4.667) 0.048 2.244(1.008-4.996)
Positive 19 20.26 ± 17.243
Vascular invasion
Negative 56 29.45 ± 15.984 0.018 2.689(1.185-6.104) 0.425
Positive 17 14.53± 11.364
Nerve invasion
Negative 61 27.8716.359 0.005 3.378(1.436-7.948) 0.271
Positive 12 16.33 ± 12.168
T stage
T1+2 50 29.16 ± 16.07 0.026 2.361(1.109-5.028)
T3+4 23 19.04 ± 14.698
TNM stage
I+II 48 30.06 ± 15.759 0.004 2.987(1.409-6.334) 0.748
III+IV 25 18.12 ± 14.438
HBs antigen
Negative 27 26.04 ± 18.797 0.274 1.515(0.720-3.185)
Positive 46 25.93 ± 14.782
Margins
Negative 67 26.90 ± 16.449 0.298 1.911(0.564-6.457)
Positive 6 15.67 ± 9.668
NDUFC1
Low 25 32.60 ± 17.376 0.016 3.330(1.252-8.858) 0.043 2.747(1.032-7.307)
High 48 22.52 ± 14.662

IHC, immunocytochemistry; LNs, lymph nodes; T, tumor; TNM, tumor-node-metastasis; HBs, hepatitis B surface; N, number; OS, overall survival; SD, standard deviation; UV, Univariable; HR, hazard ratio; CI, confidence interval; MV, multivariable.