TABLE 3.
miRNAs targeting the Wnt signaling pathway in the pathogenesis of OA.
| Name | References | Target | Main results |
|---|---|---|---|
| miR-1 | Yang Yang et al. (2021) | FZD7 | Decrease the expression of catabolic genes |
| miR-127-3p | Dong Jisheng et al. (2021) | β-Catenin | Decrease the expression of MMP-13, ADAMTS-5, TNF-α, and IL-6 |
| miR-195-5p | Yang Shu et al. (2019) | β-Catenin | Increase the expression of TNF-α, IL-6, and IL-1β in chondrocytes and induce the chondrocytes apoptosis |
| miR-27a/b | Sara Cheleschi et al. (2017) | β-Catenin | Downregulate the expression of MMP-13, ADAMTS-5, and HDAC-4 |
| miR-140 | Sara Cheleschi et al. (2017) | β-Catenin | Downregulate the expression of MMP-13, ADAMTS-5, and HDAC-4 |
| miR-146a | Sara Cheleschi et al. (2017) | β-Catenin | Downregulate the expression of MMP-13, ADAMTS-5, and HDAC-4 |
| miR-138 | Xu Weiling et al. (2019) | β-Catenin | Alleviate OA cartilage severity through increasing the level of Col2a1 and aggrecan and reducing the level of MMP-13 |
| miR-155-5p | Alessandra Colombini, et al. (2021) | β-Catenin | Protect the chondrocytes through reducing the level of MMP-1 and MMP-3 via inhibiting the Wnt signaling pathway |
| miR-34a | Sara Cheleschi, et al. (2020) | β-Catenin | Modulate the inflammation through regulating the expression of MMP-13 and ADAMTS-5 |
| miR-10a | Li J. et al. (2015) | β-Catenin | Inhibited osteogenic differentiation and decreased mouse umbilical vein endothelial cell proliferation and migration |
| miR-410 | Zhang Yanjie et al. (2017) | Wnt3a | Increase chondrogenic markers of Col2a1, Sox9, ACAN, and Has2, and alleviate OA cartilage severity |
| miR-497-5p | Hou Liying et al. (2019) | Wnt3a | Increase the expression of Col2a1 and aggrecan, and reduce the expression of MMP-13 and ADAMTS-4 |
| miR-92a-3p | Mao Guping et al. (2018) | Wnt5a | Regulate cartilage development and homeostasis |
| miR-374a-3p | Shi Feng-Lei et al. (2020) | Wnt5b | Alleviate LPS-induced damage in CHON-001 cells and inhibit cartilage injury |
| miR-1246 | Peng Sisi et al. (2021) | GSK3β and Axin2 | Promote inflammation via increasing the level of IL-6, IL-8, MMP-3, and MMP-13 |
| miR-140-3p | E. Ntoumou et al. (2017) | Wnt5a | Downregulate in the serum of OA patients and modulate the metabolic processes of OA pathology |
| miR-671-3p | E. Ntoumou et al. (2017) | Wnt5a | Downregulate in the serum of OA patients and modulate the metabolic processes of OA pathology |
| miR-33b-3p | E. Ntoumou et al. (2017) | Wnt5a | Downregulate in the serum of OA patients and modulate the metabolic processes of OA pathology |
| miR-520b | Alessandra Colombini et al. (2021) | DKK | Modulate inflammatory functions and activate the Wnt signaling pathway |
| miR-302d-3p | Alessandra Colombini et al. (2021) | DKK | Modulate inflammatory functions and activate the Wnt signaling pathway |
| miR-520c-3p | Alessandra Colombini et al. (2021) | DKK-1 | Modulate inflammatory functions and activate the Wnt signaling pathway |
| miR-154-5p | Li Jianwei et al. (2015) | Wnt11 | Inhibit osteogenic differentiation via decreasing the activity of the non-canonical Wnt/PCP (RhoA-ROCK) pathway |
| miR-26b | Sun Jilin et al. (2015) | Wnt | Inhibit the TNF-α, IL-1β, and IL-6 levels and reduce the proliferation of rheumatoid arthritis synovial fibroblasts |
| miR-335-5p | Zhang Jin et al. (2011) | DKK1 | Inhibit the osteoblasts and hypertrophic chondrocytes of mouse embryos to promote osteogenic differentiation |